Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

Aneuploidy, defined as whole chromosome gains and losses, is associated with poor patient prognosis in many cancer types. However, the condition causes cellular stress and cell cycle delays, foremost in G1 and S phase. Here, we investigate how aneuploidy causes both slow proliferation and poor disea...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Replogle, John Michael, Zhou, Wen, Amaro, Adrianna E., McFarland, James M., Villalobos-Ortiz, Mariana, Ryan, Jeremy, Letai, Anthony, Yilmaz, Omer, Sheltzer, Jason, Lippard, Stephen J., Ben-David, Uri, Amon, Angelika
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720170/
https://ncbi.nlm.nih.gov/pubmed/33203674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009506117
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