The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance

Aneuploidy—or an unbalanced karyotype in which whole chromosomes are gained or lost—causes reduced fitness at both the cellular and organismal levels but is also a hallmark of human cancers. Aneuploidy causes a variety of cellular stresses, including genomic instability, proteotoxic and oxidative st...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Dodgson, Stacie E., Santaguida, Stefano, Kim, Sharon, Sheltzer, Jason, Amon, Angelika
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110993/
https://ncbi.nlm.nih.gov/pubmed/27807036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.287474.116
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