Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

Aneuploidy, defined as whole chromosome gains and losses, is associated with poor patient prognosis in many cancer types. However, the condition causes cellular stress and cell cycle delays, foremost in G1 and S phase. Here, we investigate how aneuploidy causes both slow proliferation and poor disea...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Replogle, John Michael, Zhou, Wen, Amaro, Adrianna E., McFarland, James M., Villalobos-Ortiz, Mariana, Ryan, Jeremy, Letai, Anthony, Yilmaz, Omer, Sheltzer, Jason, Lippard, Stephen J., Ben-David, Uri, Amon, Angelika
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720170/
https://ncbi.nlm.nih.gov/pubmed/33203674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009506117
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