Tm7sf2 Disruption Alters Radial Gene Positioning in Mouse Liver Leading to Metabolic Defects and Diabetes Characteristics

Tissue-specific patterns of radial genome organization contribute to genome regulation and can be established by nuclear envelope proteins. Studies in this area often use cancer cell lines, and it is unclear how well such systems recapitulate genome organization of primary cells or animal tissues; s...

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Veröffentlicht in:Front Cell Dev Biol
Hauptverfasser: Gatticchi, Leonardo, de las Heras, Jose I., Sivakumar, Aishwarya, Zuleger, Nikolaj, Roberti, Rita, Schirmer, Eric C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Cell and Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719783/
https://ncbi.nlm.nih.gov/pubmed/33330474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.592573
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