TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2

Tripartite motif (TRIM) family proteins are important effectors of innate immunity against viral infections. Here we identified TRIM35 as a regulator of TRAF3 activation. Deficiency in or inhibition of TRIM35 suppressed the production of type I interferon (IFN) in response to viral infection. Trim35...

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Veröffentlicht in:Protein Cell
Hauptverfasser: Sun, Nan, Jiang, Li, Ye, Miaomiao, Wang, Yihan, Wang, Guangwen, Wan, Xiaopeng, Zhao, Yuhui, Wen, Xia, Liang, Libin, Ma, Shujie, Liu, Liling, Bu, Zhigao, Chen, Hualan, Li, Chengjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Higher Education Press 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719147/
https://ncbi.nlm.nih.gov/pubmed/32562145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-020-00734-6
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