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Secretion of the epithelial sodium channel chaperone PCSK9 from the cortical collecting duct links sodium retention with hypercholesterolemia in nephrotic syndrome.

The proprotein PCSK9 functions as a chaperone for the epithelial sodium channel in the cortical collecting duct (CCD), is highly expressed in the liver, and plays a significant role in the pathogenesis of hypercholesterolemia. Lower levels of PCSK9 expression also occur in the normal kidney and inte...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Kidney Int
Hauptverfasser: Molina-Jijon, Eduardo, Gambut, Stéphanie, Macé, Camille, Avila-Casado, Carmen, Clement, Lionel C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719084/
https://ncbi.nlm.nih.gov/pubmed/32750454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2020.06.045
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