Secretion of the epithelial sodium channel chaperone PCSK9 from the cortical collecting duct links sodium retention with hypercholesterolemia in nephrotic syndrome.

The proprotein PCSK9 functions as a chaperone for the epithelial sodium channel in the cortical collecting duct (CCD), is highly expressed in the liver, and plays a significant role in the pathogenesis of hypercholesterolemia. Lower levels of PCSK9 expression also occur in the normal kidney and inte...

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Publicado en:Kidney Int
Autores principales: Molina-Jijon, Eduardo, Gambut, Stéphanie, Macé, Camille, Avila-Casado, Carmen, Clement, Lionel C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719084/
https://ncbi.nlm.nih.gov/pubmed/32750454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2020.06.045
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