TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas

Metabolic rewiring is a mechanism of adaptation to unfavorable environmental conditions and tumor progression. TRAP1 is an HSP90 molecular chaperone upregulated in human colorectal carcinomas (CRCs) and responsible for downregulation of oxidative phosphorylation (OXPHOS) and adaptation to metabolic...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Maddalena, Francesca, Condelli, Valentina, Matassa, Danilo Swann, Pacelli, Consiglia, Scrima, Rosella, Lettini, Giacomo, Li Bergolis, Valeria, Pietrafesa, Michele, Crispo, Fabiana, Piscazzi, Annamaria, Storto, Giovanni, Capitanio, Nazzareno, Esposito, Franca, Landriscina, Matteo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718945/
https://ncbi.nlm.nih.gov/pubmed/33025742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12814
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