TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas

Metabolic rewiring is a mechanism of adaptation to unfavorable environmental conditions and tumor progression. TRAP1 is an HSP90 molecular chaperone upregulated in human colorectal carcinomas (CRCs) and responsible for downregulation of oxidative phosphorylation (OXPHOS) and adaptation to metabolic...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Maddalena, Francesca, Condelli, Valentina, Matassa, Danilo Swann, Pacelli, Consiglia, Scrima, Rosella, Lettini, Giacomo, Li Bergolis, Valeria, Pietrafesa, Michele, Crispo, Fabiana, Piscazzi, Annamaria, Storto, Giovanni, Capitanio, Nazzareno, Esposito, Franca, Landriscina, Matteo
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718945/
https://ncbi.nlm.nih.gov/pubmed/33025742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12814
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