Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: A novel strategy for human BRAF-driven colorectal carcinoma

The HSP90 chaperone TRAP1 is translational regulator of BRAF synthesis/ubiquitination, since BRAF down-regulation, ERK signaling inhibition and delay of cell cycle progression occur upon TRAP1 silencing/inhibition. Since TRAP1 is upregulated in human colorectal carcinomas (CRCs) and involved in prot...

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Udgivet i:Oncotarget
Main Authors: Condelli, Valentina, Maddalena, Francesca, Sisinni, Lorenza, Lettini, Giacomo, Matassa, Danilo Swann, Piscazzi, Annamaria, Palladino, Giuseppe, Amoroso, Maria Rosaria, Esposito, Franca, Landriscina, Matteo
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673164/
https://ncbi.nlm.nih.gov/pubmed/26084290
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