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Voltage and pH difference across the membrane control the S4 voltage-sensor motion of the Hv1 proton channel

The voltage-gated proton channel Hv1 is expressed in a variety of cells, including macrophages, sperm, and lung epithelial cells. Hv1 is gated by both the membrane potential and the difference between the intra- and extracellular pH (ΔpH). The coupling of voltage- and ∆pH-sensing is such that Hv1 op...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Schladt, T. Moritz, Berger, Thomas K.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718894/
https://ncbi.nlm.nih.gov/pubmed/33277511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77986-z
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