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An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1

Hv1 voltage-gated proton channels mediate rapid and selective transmembrane H(+) flux and are gated by both voltage and pH gradients. Selective H(+) transfer in membrane proteins is commonly achieved by Grotthuss proton ‘hopping’ in chains of ionizable amino acid side chains and intraprotein water m...

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Detalhes bibliográficos
Main Authors: Ramsey, I Scott, Mokrab, Younes, Carvacho, Ingrid, Sands, Zara A, Sansom, Mark S P, Clapham, David E
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035905/
https://ncbi.nlm.nih.gov/pubmed/20543828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1826
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