Genome-Wide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy

Microtubule targeting agents (MTAs) are anticancer therapies commonly prescribed for breast cancer and other solid tumors. Sensory peripheral neuropathy (PN) is the major dose-limiting toxicity for MTAs and can limit clinical efficacy. The current pharmacogenomic study aimed to identify genetic vari...

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Udgivet i:Clin Pharmacol Ther
Main Authors: Chua, Katherina C., Xiong, Chenling, Ho, Carol, Mushiroda, Taisei, Jiang, Chen, Mulkey, Flora, Lai, Dongbing, Schneider, Bryan P., Rashkin, Sara R., Witte, John S., Friedman, Paula N., Ratain, Mark J., McLeod, Howard L., Rugo, Hope S., Shulman, Lawrence N., Kubo, Michiaki, Owzar, Kouros, Kroetz, Deanna L.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718413/
https://ncbi.nlm.nih.gov/pubmed/32562552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1958
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