Inhibition of EZH2 enhances the antitumor efficacy of metformin in prostate cancer

Upregulation of EZH2 is associated with advanced stage and poor prognosis of PCa, it is therefore likely to be a promising therapeutic target. Metformin, a drug that has been used to treat type II diabetes, was found to have anti-neoplastic activity in different cancers. Herein, we report that the c...

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Udgivet i:Mol Cancer Ther
Main Authors: Kong, Yifan, Zhang, Yanquan, Mao, Fengyi, Zhang, Zhuangzhuang, Li, Zhiguo, Wang, Ruixin, Liu, Jinghui, Liu, Xiaoqi
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718407/
https://ncbi.nlm.nih.gov/pubmed/33024029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0874
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