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Association of clozapine-related metabolic disturbances with CYP3A4 expression in patients with schizophrenia
Clozapine is effective in treatment-resistant schizophrenia; however, adverse effects often result in discontinuation of clozapine therapy. Many of the side-effects are associated with pharmacokinetic variations; therefore, the expression of major clozapine-metabolizing enzymes (CYP1A2, CYP3A4) in p...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7718230/ https://ncbi.nlm.nih.gov/pubmed/33277605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78474-0 |
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