The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine

Aims Clozapine (CLZ), an atypical neuroleptic with a high risk of causing agranulocytosis, is metabolized in the liver to desmethylclozapine (DCLZ) and clozapine N-oxide (CLZ-NO). This study investigated the involvement of different CYP isoforms in the formation of these two metabolites. Methods Hum...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Eiermann, Birgit, Engel, Georg, Johansson, Inger, Zanger, Ulrich M., Bertilsson, Leif
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042873/
https://ncbi.nlm.nih.gov/pubmed/9384460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1997.t01-1-00605.x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados