Crohn’s and Parkinson’s Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14(+) Blood Monocytes Ex Vivo

The Leucine Rich Repeat Kinase 2 (LRRK2) is one of causative genes of familial Parkinson’s disease (PD). The M2397T polymorphism in LRRK2 is genetically associated with sporadic Crohn’s disease (CD). LRRK2 is expressed in human CD14(+) monocytes, induced by interferon-γ (IFN-γ) and suppresses inflam...

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Publicado en:J Neuroimmune Pharmacol
Autores principales: Ikezu, Tsuneya, Koro, Lacin, Wolozin, Benjamin, Farraye, Francis A., Strongosky, Audrey J., Wszolek, Zbigniew K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2020
Materias:
Brief Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718203/
https://ncbi.nlm.nih.gov/pubmed/32180132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-020-09909-8
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