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Crohn’s and Parkinson’s Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14(+) Blood Monocytes Ex Vivo
The Leucine Rich Repeat Kinase 2 (LRRK2) is one of causative genes of familial Parkinson’s disease (PD). The M2397T polymorphism in LRRK2 is genetically associated with sporadic Crohn’s disease (CD). LRRK2 is expressed in human CD14(+) monocytes, induced by interferon-γ (IFN-γ) and suppresses inflam...
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| Udgivet i: | J Neuroimmune Pharmacol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer US
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7718203/ https://ncbi.nlm.nih.gov/pubmed/32180132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-020-09909-8 |
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