Synthesis, computational studies and assessment of in vitro inhibitory activity of umbelliferon-based compounds against tumour-associated carbonic anhydrase isoforms IX and XII

Coumarins are widely diffused secondary metabolites possessing a plethora of biological activities. It has been established that coumarins represent a peculiar class of human carbonic anhydrase (hCA) inhibitors having a distinct mechanism of action involving a non-classical binding with amino acid r...

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Bibliografiska uppgifter
I publikationen:J Enzyme Inhib Med Chem
Huvudupphovsmän: Mancuso, Francesca, De Luca, Laura, Angeli, Andrea, Del Prete, Sonia, Capasso, Clemente, Supuran, Claudiu T., Gitto, Rosaria
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2020
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717710/
https://ncbi.nlm.nih.gov/pubmed/32614678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1786821
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