Antifibrogenic Activities of CYP11A1-derived Vitamin D3-hydroxyderivatives Are Dependent on RORγ

Previous studies showed that noncalcemic 20(OH)D(3), a product of CYP11A1 action on vitamin D(3), has antifibrotic activity in human dermal fibroblasts and in a bleomycin mouse model of scleroderma. In this study, we tested the role of retinoic acid-related orphan receptor γ (RORγ), which is express...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Janjetovic, Zorica, Postlethwaite, Arnold, Kang, Hong Soon, Kim, Tae-Kang, Tuckey, Robert C, Crossman, David K, Qayyum, Shariq, Jetten, Anton M, Slominski, Andrzej T
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717072/
https://ncbi.nlm.nih.gov/pubmed/33107570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/endocr/bqaa198
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