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Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?
Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA Class I hyperexpression and islet infiltrates dominated by CD8(+) T cells. While...
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| Publicado no: | Diabetologia |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7717061/ https://ncbi.nlm.nih.gov/pubmed/33084970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-020-05298-y |
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