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Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA Class I hyperexpression and islet infiltrates dominated by CD8(+) T cells. While...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Diabetologia
Päätekijät: Carré, Alexia, Richardson, Sarah J., Larger, Etienne, Mallone, Roberto
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer Berlin Heidelberg 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717061/
https://ncbi.nlm.nih.gov/pubmed/33084970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-020-05298-y
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