RNA Drug discovery: Conformational restriction enhances specific modulation of the T-Box riboswitch function

Antibacterial drug resistance is a global health concern that requires multiple solution approaches including development of new antibacterial compounds acting at novel targets. Targeting regulatory RNA is an emerging area of drug discovery. The T-box riboswitch is a regulatory RNA mechanism that co...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Armstrong, Ian, Aldhumani, Ali H., Schopis, Jia L., Fang, Fang, Parsons, Eric, Zeng, Chunxi, Hossain, Md. Ismail, Bergmeier, Stephen C., Hines, Jennifer V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716477/
https://ncbi.nlm.nih.gov/pubmed/33069065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115696
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