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Factors that influence T box riboswitch efficacy and tRNA affinity

The T box riboswitch is an intriguing potential target for antibacterial drug discovery. Found primarily in Gram-positive bacteria, the riboswitch regulates gene expression by selectively responding to uncharged tRNA to control transcription readthrough. Polyamines and molecular crowding are known t...

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Bibliografische gegevens
Gepubliceerd in:Bioorg Med Chem
Hoofdauteurs: Zeng, C., Zhou, S., Bergmeier, S.C., Hines, J.V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562017/
https://ncbi.nlm.nih.gov/pubmed/26220520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.018
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