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Factors that influence T box riboswitch efficacy and tRNA affinity
The T box riboswitch is an intriguing potential target for antibacterial drug discovery. Found primarily in Gram-positive bacteria, the riboswitch regulates gene expression by selectively responding to uncharged tRNA to control transcription readthrough. Polyamines and molecular crowding are known t...
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| Udgivet i: | Bioorg Med Chem |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4562017/ https://ncbi.nlm.nih.gov/pubmed/26220520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.018 |
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