Definition of Smad3 Phosphorylation Events That Affect Malignant and Metastatic Behaviors in Breast Cancer Cells

Smad3, a major intracellular mediator of TGFβ signaling, functions as both a positive and negative regulator in carcinogenesis. In response to TGFβ, the TGFβ receptor phosphorylates serine residues at the Smad3 C-tail. Cancer cells often contain high levels of the MAPK and CDK activities, which can...

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Dettagli Bibliografici
Pubblicato in:Cancer Res
Autori principali: Bae, Eunjin, Sato, Misako, Kim, Ran-Ju, Kwak, Mi-Kyung, Naka, Kazuhito, Gim, Jungsoo, Kadota, Mitsutaka, Tang, Binwu, Flanders, Kathleen C., Kim, Tae-Aug, Leem, Sun-Hee, Park, Taesung, Liu, Fang, Wakefield, Lalage M., Kim, Seong-Jin, Ooshima, Akira
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716116/
https://ncbi.nlm.nih.gov/pubmed/25205100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0803
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