Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

Tubulointerstitial fibrosis is the final common result of a variety of progressive injuries leading to chronic renal failure. Transforming growth factor-β (TGF-β) is reportedly upregulated in response to injurious stimuli such as unilateral ureteral obstruction (UUO), causing renal fibrosis associat...

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Hlavní autoři: Sato, Misako, Muragaki, Yasuteru, Saika, Shizuya, Roberts, Anita B., Ooshima, Akira
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2003
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC259132/
https://ncbi.nlm.nih.gov/pubmed/14617750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200319270
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