TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury

Transforming growth factor-β (TGFβ) is activated as a result of liver injury, such as cholestasis. However, its influence on endogenous metabolism is not known. This study demonstrated that TGFβ regulates hepatic phospholipid and bile acid homeostasis through MAD homolog 3 (SMAD3) activation as reve...

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Detalhes bibliográficos
Main Authors: Matsubara, Tsutomu, Tanaka, Naoki, Sato, Misako, Kang, Dong Wook, Krausz, Kristopher W., Flanders, Kathleen C., Ikeda, Kazuo, Luecke, Hans, Wakefield, Lalage M., Gonzalez, Frank J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494264/
https://ncbi.nlm.nih.gov/pubmed/23034213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M031773
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