HGG-18. CLINICAL EFFICACY OF ONC201 IN THALAMIC H3 K27M-MUTANT GLIOMA

ONC201, a bitopic DRD2 antagonist and allosteric ClpP agonist, has shown encouraging efficacy in H3 K27M-mutant glioma. Given that the thalamus has the highest extra-striatal expression of DRD2, we performed an integrated preclinical and clinical analysis of ONC201 in thalamic H3 K27M-mutant glioma....

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Kawakibi, Abed Rahman, Tarapore, Rohinton S, Gardner, Sharon, Chi, Andrew, Kurz, Sylvia, Wen, Patrick Y, Arrillaga-Romany, Isabel, Batchelor, Tracy T, Butowski, Nicholas A, Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca, DeGroot, John, Mehta, Minesh, Odia, Yazmin, Hall, Matthew D, Daghistani, Doured, Cloughesy, Timothy F, Ellingson, Benjamin M, Umemura, Yoshie, Schwartz, Jonathan, Yadav, Vivekanand, Cartaxo, Rodrigo, Siada, Ruby, Miklja, Zachary, Bruzek, Amy, Cantor, Evan, Wierzbicki, Kyle, Paul, Alyssa, Wolfe, Ian, Leaoard, Marcia, Garton, Hugh, Mody, Rajen, Robertson, Patricia L, Lu, Guangrong, Merdinger, Krystal, Venneti, Sriram, Oster, Wolfgang, Allen, Joshua E, Koschmann, Carl
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
High Grade Glioma
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715973/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.305
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