HGG-18. CLINICAL EFFICACY OF ONC201 IN THALAMIC H3 K27M-MUTANT GLIOMA

ONC201, a bitopic DRD2 antagonist and allosteric ClpP agonist, has shown encouraging efficacy in H3 K27M-mutant glioma. Given that the thalamus has the highest extra-striatal expression of DRD2, we performed an integrated preclinical and clinical analysis of ONC201 in thalamic H3 K27M-mutant glioma....

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發表在:Neuro Oncol
Main Authors: Kawakibi, Abed Rahman, Tarapore, Rohinton S, Gardner, Sharon, Chi, Andrew, Kurz, Sylvia, Wen, Patrick Y, Arrillaga-Romany, Isabel, Batchelor, Tracy T, Butowski, Nicholas A, Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca, DeGroot, John, Mehta, Minesh, Odia, Yazmin, Hall, Matthew D, Daghistani, Doured, Cloughesy, Timothy F, Ellingson, Benjamin M, Umemura, Yoshie, Schwartz, Jonathan, Yadav, Vivekanand, Cartaxo, Rodrigo, Siada, Ruby, Miklja, Zachary, Bruzek, Amy, Cantor, Evan, Wierzbicki, Kyle, Paul, Alyssa, Wolfe, Ian, Leaoard, Marcia, Garton, Hugh, Mody, Rajen, Robertson, Patricia L, Lu, Guangrong, Merdinger, Krystal, Venneti, Sriram, Oster, Wolfgang, Allen, Joshua E, Koschmann, Carl
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
主題:
High Grade Glioma
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715973/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.305
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