IMMU-03. UPDATES ON BRAINCHILD-01, -02, AND -03: PHASE 1 LOCOREGIONAL CAR T CELL TRIALS TARGETING HER2, EGFR, AND B7-H3 FOR CHILDREN WITH RECURRENT CNS TUMORS AND DIPG

We report preliminary results of three Phase 1 trials of repetitively dosed locoregional CAR T cells for children with recurrent/refractory CNS tumors, targeting HER2 (BrainChild-01), EGFR (BrainChild-02), and B7-H3 (BrainChild-03). Cells are delivered into the tumor cavity (Arm A) or ventricular sy...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Vitanza, Nicholas, Gust, Juliane, Wilson, Ashley, Huang, Wenjun, Perez, Francisco, Wright, Jason, Leary, Sarah, Cole, Bonnie, Albert, Catherine, Pinto, Navin, Orentas, Rimas, Jensen, Michael, Park, Julie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Immunotherapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715908/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.360
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