IMMU-02. LOCOREGIONAL HER2CAR T CELLS FOR PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS: PRECLINICAL EFFICACY TO TOLERABILITY IN FIRST PATIENT

Chimeric antigen receptor (CAR) T cell therapy provides a broadly applicable, targeted, yet pathway-independent, intervention for pediatric central nervous system (CNS) tumors. We have optimized the efficacy and specificity of a HER2-targeted CAR with an extracellular target-specific scFv domain der...

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Dades bibliogràfiques
Publicat a:Neuro Oncol
Autors principals: Vitanza, Nicholas, Johnson, Adam, Beebe, Adam, Gust, Juliane, Hauptman, Jason, Hoeppner, Corrine, Wilson, Ashley, Perez, Francisco, Pinto, Navin, Orenta, Rimas, Finn, Laura, Gardner, Rebecca, Park, Julie, Jensen, Michael
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Immunology/Immunotherapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477237/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.123
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