HGG-26. H3G34V MUTATION AFFECTS GENOMIC H3K36 METHYLATION IN PEDIATRIC GLIOMA

BACKGROUND: Histone H3.3 mutation (H3F3A) occurs in 50% of cortical pediatric high-grade gliomas. This mutation replaces glycine 34 with arginine or valine (G34R/V), impairing SETD2 activity (H3K36-specific trimethyltransferase), resulting in reduced H3K36me on H3G34V nucleosomes relative to wild-ty...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Huang, Tina, Piunti, Andrea, Bartom, Elizabeth, Qi, Jin, Hashizume, Rintaro, Shilatifard, Ali, Saratsis, Amanda
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
High Grade Glioma
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715899/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.310
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