DIPG-18. IDENTIFICATION OF TARGETABLE PATHWAY DEPENDENCIES IN DIFFUSE INTRINSIC PONTINE GLIOMA

Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive paediatric brainstem tumour with a dismal prognosis. Recurrent heterozygous mutations (p.K27M) in Histone H3 variant genes have been identified in the majority of DIPG cases. While the exact mechanism of H3K27M’s function is poorly under...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Parackal, Sarah, Chong, Wai Chin, Bradshaw, Gabrielle, Sun, Claire, Daniel, Paul, Roussel, Enola, Jayasekara, Samantha, Crombie, Duncan, Firestein, Ron, Cain, Jason
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Diffuse Midline Glioma/DIPG
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715817/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.068
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