TBIO-12. THE SPECTRUM OF MITOCHONDRIAl DNA (mtDNA) MUTATIONS IN PEDIATRIC CENTRAL NERVOUS SYSTEM (CNS) TUMORS

To explore the role of mitochondrial DNA mutations in pediatric CNS tumors, we analyzed 749 tumor-normal paired whole genome sequencing data sets from the Children’s Brain Tumor Tissue Consortium (CBTTC). We detected 307 somatic mtDNA mutations in 222 CNS tumors (29.6%). Most frequently observed wer...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Kaneva, Kristiyana, Triska, Petr, Merkurjev, Daria, Bootwalla, Moiz, Cotter, Jennifer, Ostrow, Dejerianne, O’Halloran, Katrina, Biegel, Jaclyn, Gai, Xiaowu
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Tumor Biology (not fitting a specific disease category)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715789/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.839
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