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Detection of mitochondrial DNA variants at low level heteroplasmy in pediatric CNS and extra-CNS solid tumors with three different enrichment methods

The mitochondrial genome is small, 16.5kb, and yet complex to study due to an abundance of mitochondria in any given cell or tissue. Mitochondrial DNA (mtDNA) mutations have been previously described in cancer, many of which were detected at low heteroplasmy. In this study we enriched the mitochondr...

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Detalhes bibliográficos
Publicado no:Mitochondrion
Main Authors: Kaneva, Kristiyana, Merkurjev, Daria, Ostrow, Dejerianne, Ryutov, Alex, Triska, Petr, Stachelek, Kevin, Cobrinik, David, Biegel, Jaclyn A., Gai, Xiaowu
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502000/
https://ncbi.nlm.nih.gov/pubmed/31972374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2020.01.006
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