IMMU-18. FAVORABLE OUTCOME IN REPLICATION REPAIR DEFICIENT HYPERMUTANT BRAIN TUMORS TO IMMUNE CHECKPOINT INHIBITION: AN INTERNATIONAL RRD CONSORTIUM REGISTRY STUDY

Pediatric brain tumors with replication repair deficiency (RRD) are hypermutant and may respond to immune checkpoint inhibition (ICI). We performed a consortium registry study of ICI in recurrent RRD cancers. Clinical and companion biomarkers were collected longitudinally on all patients. Biomarkers...

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Pubblicato in:Neuro Oncol
Autori principali: Bouffet, Eric, Sudhaman, Sumedha, Chung, Jiil, Kelly, Jacalyn, Coblentz, Ailish, Edwards, Melissa, Lipman, Tatiana, Zhang, Cindy, Ercan, Ayse Bahar, Sambira, Lauren, Bendel, Anne, Bielack, Stefan, Koustenis, Elisabeth, Blumenthal, Deborah, Bowers, Daniel, Broniscer, Alberto, Bronsema, Annika, Carroll, Sara, Chiaravalli, Stefano, Cole, Kristina, Constantini, Shlomi, De Mola, Rebecca Loret, Dunn, Gavin, Fröjd, Charlotta, Gass, David, Gauvain, Karen, George, Ben, Hijiya, Nobuko, Hoffman, Lindsey, Knipstein, Jeffrey, Laetsch, Ted, Larouche, Valérie, Lassaletta, Alvaro, Lindhorst, Scott, Lossos, Alexander, Luna-Fineman, Sandra, Magimairajan, Vanan, Mason, Gary, Mason, Warren, Massimino, Maura, Mordechai, Oz, Opocher, Enrico, Oren, Michal, Osborn, Michael, Reddy, Alyssa, Remke, Mark, Roy, Sumita, Sabel, Magnus, Samuel, David, Schneider, Kami, Sen, Santanu, Stearns, Duncan, Sumerauer, David, Thomas, Gregory, Tomboc, Patrick, Van Damme, An, Wierman, Margaret, Winer, Ira, Yen, Lee Yi, Zapotocky, Michal, Ziegler, David, Zimmermann, Stefanie, Dvir, Rina, Rechavi, Gidi, Durno, Carol, Aronson, Melyssa, Taylor, Michael, Dirks, Peter, Pugh, Trevor, Shlien, Adam, Hawkins, Cynthia, Morgenstern, Daniel, Tabori, Uri
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Immunotherapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715575/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.374
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