IMMU-18. FAVORABLE OUTCOME IN REPLICATION REPAIR DEFICIENT HYPERMUTANT BRAIN TUMORS TO IMMUNE CHECKPOINT INHIBITION: AN INTERNATIONAL RRD CONSORTIUM REGISTRY STUDY

Pediatric brain tumors with replication repair deficiency (RRD) are hypermutant and may respond to immune checkpoint inhibition (ICI). We performed a consortium registry study of ICI in recurrent RRD cancers. Clinical and companion biomarkers were collected longitudinally on all patients. Biomarkers...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Bouffet, Eric, Sudhaman, Sumedha, Chung, Jiil, Kelly, Jacalyn, Coblentz, Ailish, Edwards, Melissa, Lipman, Tatiana, Zhang, Cindy, Ercan, Ayse Bahar, Sambira, Lauren, Bendel, Anne, Bielack, Stefan, Koustenis, Elisabeth, Blumenthal, Deborah, Bowers, Daniel, Broniscer, Alberto, Bronsema, Annika, Carroll, Sara, Chiaravalli, Stefano, Cole, Kristina, Constantini, Shlomi, De Mola, Rebecca Loret, Dunn, Gavin, Fröjd, Charlotta, Gass, David, Gauvain, Karen, George, Ben, Hijiya, Nobuko, Hoffman, Lindsey, Knipstein, Jeffrey, Laetsch, Ted, Larouche, Valérie, Lassaletta, Alvaro, Lindhorst, Scott, Lossos, Alexander, Luna-Fineman, Sandra, Magimairajan, Vanan, Mason, Gary, Mason, Warren, Massimino, Maura, Mordechai, Oz, Opocher, Enrico, Oren, Michal, Osborn, Michael, Reddy, Alyssa, Remke, Mark, Roy, Sumita, Sabel, Magnus, Samuel, David, Schneider, Kami, Sen, Santanu, Stearns, Duncan, Sumerauer, David, Thomas, Gregory, Tomboc, Patrick, Van Damme, An, Wierman, Margaret, Winer, Ira, Yen, Lee Yi, Zapotocky, Michal, Ziegler, David, Zimmermann, Stefanie, Dvir, Rina, Rechavi, Gidi, Durno, Carol, Aronson, Melyssa, Taylor, Michael, Dirks, Peter, Pugh, Trevor, Shlien, Adam, Hawkins, Cynthia, Morgenstern, Daniel, Tabori, Uri
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715575/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.374
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