LGG-25. A PHASE 2 STUDY OF TRAMETINIB FOR PATIENTS WITH PEDIATRIC GLIOMA WITH ACTIVATION OF THE MAPK/ERK PATHWAY. TRAM-01

BACKGROUND: Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. It is now known that the majority of PLGG have activation of the MAPK/ERK pathway. We hypothesize that we will observe responses in recurrent/refractory PLGG treated with trametinib. METHODS: This is a mul...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Perreault, Sébastien, Larouche, Valérie, Tabori, Uri, Hawkins, Cynthia, Lippé, Sarah, Ellezam, Benjamin, Décarie, Jean-Claude, Théoret, Yves, Métras, Marie-Élaine, Sultan, Serge, Cantin, Édith, Routhier, Marie-Ève, Caru, Maxime, Legault, Geneviève, Bouffet, Eric, Lafay-Cousin, Lucie, Hukin, Juliette, Erker, Craig, Jabado, Nada
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Low Grade Glioma
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715510/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.407
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