LGG-49. SAFETY AND EFFICACY OF TRAMETINIB (T) MONOTHERAPY AND DABRAFENIB + TRAMETINIB (D+T) COMBINATION THERAPY IN PEDIATRIC PATIENTS WITH BRAF V600-MUTANT LOW-GRADE GLIOMA (LGG)

BACKGROUND: Children with BRAF V600-mutant LGG have suboptimal response to standard chemotherapy. Previously, D (BRAF V600 inhibitor) monotherapy has demonstrated clinical benefit in this population. We report interim analysis results of pediatric patients with recurrent/refractory BRAF V600-mutant...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Bouffet, Eric, Whitlock, James A, Moertel, Christopher, Geoerger, Birgit, Aerts, Isabelle, Hargrave, Darren, Cohen, Kenneth J, Kilburn, Lindsay B, Upadhyaya, Santhosh A, Wetmore, Cynthia, Wright, Karen D, Choi, Jeea, Gasal, Eduard, Russo, Mark W, Fox, Elizabeth
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Low Grade Glioma
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715318/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.427
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