LGG-49. SAFETY AND EFFICACY OF TRAMETINIB (T) MONOTHERAPY AND DABRAFENIB + TRAMETINIB (D+T) COMBINATION THERAPY IN PEDIATRIC PATIENTS WITH BRAF V600-MUTANT LOW-GRADE GLIOMA (LGG)

BACKGROUND: Children with BRAF V600-mutant LGG have suboptimal response to standard chemotherapy. Previously, D (BRAF V600 inhibitor) monotherapy has demonstrated clinical benefit in this population. We report interim analysis results of pediatric patients with recurrent/refractory BRAF V600-mutant...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Bouffet, Eric, Whitlock, James A, Moertel, Christopher, Geoerger, Birgit, Aerts, Isabelle, Hargrave, Darren, Cohen, Kenneth J, Kilburn, Lindsay B, Upadhyaya, Santhosh A, Wetmore, Cynthia, Wright, Karen D, Choi, Jeea, Gasal, Eduard, Russo, Mark W, Fox, Elizabeth
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2020
Ämnen:
Low Grade Glioma
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715318/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.427
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