CTNI-24. A PHASE 2 STUDY OF TRAMETINIB FOR PATIENTS WITH PEDIATRIC GLIOMA WITH ACTIVATION OF THE MAPK/ERK PATHWAY. TRAM-01

BACKGROUND: Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. It is known that the majority of PLGG have activation of the MAPK/ERK pathway. METHODS: This multicenter phase II included three progressing/refractory PLGG groups: NF1 patients, KIAA1549-BRAF fusion patie...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Perreault, Sébastien, larouche, Valérie, Tabori, Uri, Hawkins, Cynthia, Lippe, Sarah, Ellezam, Benjamin, Décarie, Jean-Claude, Théoret, Yves, Metras, Marie-Élaine, Sultan, Serge, Cantin, Édith, Routhier, Marie-Ève, Caru, Maxime, Legault, Geneviève, Bouffet, Eric, Lafay-Cousin, Lucie, Hukin, Juliette, Erker, Craig, Jabado, Nada
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
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Clinical Trials: Non-Immunologic
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650427/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.191
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