IMMU-19. HDAC INHIBITORS SENSITIZE MYC-AMPLIFIED MEDULLOBLASTOMA TO IMMUNOTHERAPY BY ACTIVATING THE NF-kB PATHWAYS

Medulloblastoma is the most common malignant brain tumor in childhood and comprises four distinct molecular subgroups with further layers of intertumoral heterogeneity. Amplification of the oncogene MYC drives tumorigenesis and constitutes a hallmark feature underlying Group 3 biology. Employing our...

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Publicado en:Neuro Oncol
Autores principales: Marquardt, Viktoria, Theruvath, Johanna, Pauck, David, Picard, Daniel, Reifenberger, Guido, Borkhardt, Arndt, Cheshier, Samuel, Kurz, Thomas, Remke, Marc, Mitra, Siddhartha
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Immunotherapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715498/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.375
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