IMMU-19. HDAC INHIBITORS SENSITIZE MYC-AMPLIFIED MEDULLOBLASTOMA TO IMMUNOTHERAPY BY ACTIVATING THE NF-kB PATHWAYS

Medulloblastoma is the most common malignant brain tumor in childhood and comprises four distinct molecular subgroups with further layers of intertumoral heterogeneity. Amplification of the oncogene MYC drives tumorigenesis and constitutes a hallmark feature underlying Group 3 biology. Employing our...

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Опубликовано в: :Neuro Oncol
Главные авторы: Marquardt, Viktoria, Theruvath, Johanna, Pauck, David, Picard, Daniel, Reifenberger, Guido, Borkhardt, Arndt, Cheshier, Samuel, Kurz, Thomas, Remke, Marc, Mitra, Siddhartha
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
Immunotherapy
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715498/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.375
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