IMMU-19. HDAC INHIBITORS SENSITIZE MYC-AMPLIFIED MEDULLOBLASTOMA TO IMMUNOTHERAPY BY ACTIVATING THE NF-kB PATHWAYS

Medulloblastoma is the most common malignant brain tumor in childhood and comprises four distinct molecular subgroups with further layers of intertumoral heterogeneity. Amplification of the oncogene MYC drives tumorigenesis and constitutes a hallmark feature underlying Group 3 biology. Employing our...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Marquardt, Viktoria, Theruvath, Johanna, Pauck, David, Picard, Daniel, Reifenberger, Guido, Borkhardt, Arndt, Cheshier, Samuel, Kurz, Thomas, Remke, Marc, Mitra, Siddhartha
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Immunotherapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715498/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.375
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