DIPG-12. TARGETING EPIGENETIC MODIFIERS TO INDUCE IMMUNE SIGNALING IN DIPG

DIPG is a universally fatal pediatric brainstem tumor with no effective therapy. Recent work has shown that over 80% of DIPG cases harbor the H3K27M mutation leading to global loss of the repressive H3K27 trimethylation mark, global DNA hypomethylation, and a distinct gene expression signature. We s...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Tetens, Ashley, Martin, Allison, Arnold, Antje, Novak, Orlandi, Eberhart, Charles, Feinberg, Andrew, Raabe, Eric, Koldobskiy, Michael
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Diffuse Midline Glioma/DIPG
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715404/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.062
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