MBRS-46. CHARTING NEOPLASTIC AND IMMUNE CELL HETEROGENEITY IN HUMAN AND GEM MODELS OF MEDULLOBLASTOMA USING scRNAseq

We explored cellular heterogeneity in medulloblastoma using single-cell RNA sequencing (scRNAseq), immunohistochemistry and deconvolution of bulk transcriptomic data. Over 45,000 cells from 31 patients from all main subgroups of medulloblastoma (2 WNT, 10 SHH, 9 GP3, 11 GP4 and 1 GP3/4) were cluster...

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Vydáno v:Neuro Oncol
Hlavní autoři: Donson, Andrew, Riemondy, Kent, Venkataraman, Sujatha, Gilani, Ahmed, Sanford, Bridget, Griesinger, Andrea, Amani, Vladimir, Hankinson, Todd, Handler, Michael, Hesselberth, Jay, Gershon, Timothy, Wechsler-Reya, Robert, Foreman, Nicholas, Vibhakar, Rajeev
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Medulloblastoma (Research)
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715400/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.555
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