MBRS-59. SINGLE-CELL WHOLE-GENOME SEQUENCING DISSECTS INTRA-TUMOURAL GENOMIC HETEROGENEITY AND CLONAL EVOLUTION IN CHILDHOOD MEDULLOBLASTOMA

Medulloblastomas harbor clinically-significant intra-tumoral heterogeneity for key biomarkers (e.g. MYC/MYCN, β-catenin). Recent studies have characterized transcriptional heterogeneity at the single-cell level, however the underlying genomic copy number and mutational architecture remains to be res...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Danilenko, Marina, Zaka, Masood, Keeling, Claire, Crosier, Stephen, Hussain, Rafiqul, Schwalbe, Edward, Williamson, Dan, Coxhead, Jonathan, Rand, Vikki, Bailey, Simon, Clifford, Steven
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Medulloblastoma (Research)
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715334/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.563
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