DDEL-09. HIGH DOSE MTX110 (SOLUBLE PANOBINOSTAT) SAFELY ADMINISTERED INTO THE FOURTH VENTRICLE IN A NON-HUMAN PRIMATE MODEL

OBJECTIVE: This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma, UK) into the fourth ventricle of non-human primates. METHODS: Four rhesus macaque monkeys underwent posterior fossa craniectomy and catheter inser...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Sirianni, Rachael W, Kharas, Natasha, Yu, Bangning, Janssen, Christopher F, Trimble, Amanda, Ballester, Leomar Y, Patel, Rajan, Mohammad, Afroz S, Elmquist, William F, Sandberg, David I
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Drug Delivery/Pharmacokinetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715323/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.044
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