EPEN-22. SINGLE-CELL RNA SEQUENCING IDENTIFIES UPREGULATION OF IKZF1 IN PFA2 MYELOID SUBPOPULATION DRIVING AN ANTI-TUMOR PHENOTYPE

We have previously shown immune gene phenotype variations between posterior fossa ependymoma subgroups. PFA1 tumors chronically secrete IL-6, which pushes the infiltrating myeloid cells to an immune suppressive function. In contrast, PFA2 tumors have a more immune activated phenotype and have a bett...

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Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Griesinger, Andrea, Prince, Eric, Donson, Andrew, Riemondy, Kent, Ritzman, Timothy, Harris, Faith, Amani, Vladimir, Handler, Michael, Hankinson, Todd, Grundy, Richard, Jackson, Andrew, Foreman, Nicholas
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Ependymoma
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715268/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.159
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