DIPG-41. DISSECTING THE MECHANISTIC BASIS FOR ACVR1 AND PIK3CA MUTATION CO-OCCURRENCE IN DIFFUSE MIDLINE GLIOMAS USING GENETICALLY ENGINEERED MOUSE MODELS

Diffuse midline gliomas (DMGs) are aggressive childhood brain tumors with a dismal prognosis. Most of these tumors carry K27M mutations in histone H3-encoding genes, particularly H3F3A and HIST1H3B. In addition, activating mutations in ACVR1 and PIK3CA co-occur in a subset of DMGs. To understand how...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Wu, Annette, Mak, Tak, Fortin, Jerome
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Diffuse Midline Glioma/DIPG
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715261/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.088
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