DDEL-05. BLOOD-BRAIN BARRIER DISRUPTION AND ENHANCED RADIOSENSITIZERS EXTRAVASATION UPON FOCUSED ULTRASOUND FOR TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA

Poor prognosis of diffuse midline glioma, including diffuse intrinsic pontine glioma (DIPG), reflects the low efficacy of current treatment strategies, mainly due to (1) a largely intact blood-brain barrier (BBB) and (2) the proficiency of tumour tissues to upregulate multiple DNA repair genes, resu...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Hart, Elvin ‘t, Derieppe, Marc, Bruin, Maaike, Besse, Helena, Haumann, Rianne, Hoving, Eelco, Huitema, Alwin, Ries, Mario, van Vuurden, Dannis
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Drug Delivery/Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715181/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.040
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