Wnt pathway modulation generates blastomere-derived mouse embryonic stem cells with different pluripotency features

PURPOSE: This study aimed to determine the role of Wnt pathway in mouse embryonic stem cell (mESC) derivation from single blastomeres isolated from eight-cell embryos and in the pluripotency features of the mESC established. METHODS: Wnt activator CHIR99021, Wnt inhibitor IWR-1-endo, and MEK inhibit...

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Bibliografiske detaljer
Udgivet i:J Assist Reprod Genet
Main Authors: Vila-Cejudo, Marta, Alonso-Alonso, Sandra, Pujol, Anna, Santaló, Josep, Ibáñez, Elena
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2020
Fag:
Technological Innovations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714892/
https://ncbi.nlm.nih.gov/pubmed/33047186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-020-01964-7
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