Cleavage of hepatocyte growth factor activator inhibitor‐1 by membrane‐type MMP‐1 activates matriptase

Co‐expression of membrane‐type 1 (MT1)‐MMP with hepatocyte growth factor activator inhibitor‐1 (HAI‐1) in HEK293T cells resulted in cleavage of HAI‐1 to produce three fragments. Recombinant MT1‐MMP was shown to cleave HAI‐1 protein in vitro. Hepatocyte growth factor activator inhibitor‐1 was initial...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Domoto, Takahiro, Takino, Takahisa, Guo, Luyang, Sato, Hiroshi
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2012
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7713627/
https://ncbi.nlm.nih.gov/pubmed/22118498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2011.02162.x
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